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In this exciting original research published in Science on May 20th, 6 DNA vaccine candidates targeting SARS-CoV-2 were tested in rhesus macaque primates. At the start of the study 35 animals were treated with the vaccines followed by a booster dose at week 3. By week 5 all of the vaccinated animals demonstrated appropriate immune response. At week 6 the animals were exposed to SARS-CoV-2. Viral load was found to be significantly lower in the immunized animals vs. control. Of the 6 candidate vaccines tested, some variants demonstrated stronger protections than others, with some of the animals developing no detectable virus at any time point, while others developed mild symptoms. This very exciting early research not only demonstrates a potentially effective vaccine against SARS-CoV-2, but also develops the framework by which a vaccine could be tested and refined.
Please click here to view the original article from Science.